Autophagy defects in Lafora disease

Puri, Rajat ; Ganesh, Subramaniam (2012) Autophagy defects in Lafora disease Autophagy, 8 (2). pp. 289-290. ISSN 1554-8627

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Lafora disease (LD) is an inherited and fatal form of neurodegenerative disorder characterized by the presence of an abnormal form of glycogen inclusions, called Lafora bodies, in neurons and other tissues. While Lafora bodies have been thought to underlie the neuropathology in LD, the specific process by which these inclusions might affect the neuronal functions was not very well understood. Here we review one of our recent studies on the LD animal model, wherein we have shown that the Lafora bodies might contribute to the impairment in the endosomal–lysosomal and autophagy pathways.

Item Type:Article
Source:Copyright of this article belongs to Taylor & Francis.
Keywords:Epilepsy; Endosomal Defects; Intracellular Amyloid-Β Deposits; Neurodegenerative Disorder; Polyglucosan Inclusion
ID Code:101673
Deposited On:03 Feb 2017 16:52
Last Modified:01 Feb 2018 12:01

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