Jain, Navodita ; Ganesh, Subramaniam (2016) Emerging nexus between RAB GTPases, autophagy and neurodegeneration Autophagy, 12 (5). pp. 900-904. ISSN 1554-8627
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Official URL: http://www.tandfonline.com/doi/full/10.1080/155486...
Related URL: http://dx.doi.org/10.1080/15548627.2016.1147673
Abstract
The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor & Francis. |
| Keywords: | Autophagy; Endocytosis; GTPase; Intracellular Trafficking; Neurodegeneration; Neuronal Maintenance; RAB Proteins; Stress Response |
| ID Code: | 101376 |
| Deposited On: | 03 Feb 2017 17:05 |
| Last Modified: | 01 Feb 2018 12:01 |
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