A mild and chemoselective method for ester O-alkyl cleavage using in situ generated potassium thiophenoxide from catalytic quantities of base

Sharma, Lalima ; Nayak, Mrinal K. ; Chakraborti, Asit K. (1999) A mild and chemoselective method for ester O-alkyl cleavage using in situ generated potassium thiophenoxide from catalytic quantities of base Tetrahedron, 55 (31). pp. 9595-9600. ISSN 0040-4020

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0040-4020(99)00505-0

Abstract

Chemoselective deprotection of methyl esters can be achieved under non-hydrolytic and virtually neutral conditions by treatment with thiophenol in N-methyl-2-pyrrolidone (NMP) in the presence of a catalytic amount of K2CO3.

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