Bhowmick, Krishanu ; Dhar, Suman K. (2014) Plasmodium falciparum single-stranded DNA-binding protein (PfSSB) interacts with PfPrex helicase and modulates its activity FEMS Microbiology Letters, 351 (1). pp. 78-87. ISSN 0378-1097
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Official URL: http://femsle.oxfordjournals.org/content/351/1/78
Related URL: http://dx.doi.org/10.1111/1574-6968.12343
Abstract
Plasmodium falciparum (Pf) apicoplast is an essential organelle harbouring a ~35-kb circular genome. Prokaryotic nature of this organelle and its components makes it an attractive therapeutic target. The single-stranded DNA-binding protein (SSB) and multidomain protein PfPrex are important apicoplast replication proteins. However, regulation of these proteins through protein–protein interaction remains largely unknown. Here, we report that P. falciparum single-stranded DNA-binding protein (PfSSB) interacts with PfPrex helicase and modulates its activity. N-terminal domain of PfSSB is involved in this interaction, whereas C-terminal domain plays a pivotal role in the modulation of helicase activity. These results further, to our knowledge, understand apicoplast DNA replication.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Oxford University Press. |
| Keywords: | Plasmodium falciparum; Apicoplast; Single-stranded DNA-Binding Protein (SSB); PfPrex Helicase; Replication |
| ID Code: | 100983 |
| Deposited On: | 12 Feb 2018 12:11 |
| Last Modified: | 12 Feb 2018 12:11 |
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