A generalized Langevin formalism of complete DNA melting transition

Das, T. ; Chakraborty, S. (2008) A generalized Langevin formalism of complete DNA melting transition EPL (Europhysics Letters), 83 (4). Article ID 48003. ISSN 0295-5075

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Official URL: http://iopscience.iop.org/article/10.1209/0295-507...

Related URL: http://dx.doi.org/10.1209/0295-5075/83/48003

Abstract

Melting transition of double-stranded oligonucleotide sequences, in contact with a Langevin fluctuation-dissipation thermal bath, is investigated. A general framework for studying stochastic phase transitions in single dimension is developed for realistic regimes of temperatures, by postulating base pair separation-dependent damping characteristics in the Langevin formalism. Close agreements are obtained between the simulation predictions and the experimental results for heterogeneous DNA sequences having a wide range of sequence lengths, without incurring any sequence-specific tuning of the conventional Peyrard-Bishop-Dauxois model. Certain universal characteristics of the free energy parameters of melting transition are also discovered, with a power law form of temperature dependence.

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