Nanodiamonds activate blood platelets and induce thromboembolism

Kumari, Sharda ; Singh, Manoj K. ; Singh, Sunil K. ; Gracio, Jose J. A. ; Dash, Debabrata (2014) Nanodiamonds activate blood platelets and induce thromboembolism Nanomedicine, 9 (3). pp. 427-440. ISSN 1743-5889

Full text not available from this repository.

Official URL:

Related URL:


Aim: Nanodiamonds (NDs) have been evaluated for a wide range of biomedical applications. Thus, thorough investigation of the biocompatibility of NDs has become a research priority. Platelets are highly sensitive and are one of the most abundant cell types found in blood. They have a central role in hemostasis and arterial thrombosis. In this study, we aim to investigate the direct and acute effects of carboxylated NDs on platelet function. Methods: In this study, pro-coagulant parameters such as platelet aggregability, intracellular Ca2+ flux, mitochondrial transmembrane potential (ΔΨm), generation of reactive oxygen species, surface exposure of phosphatidylserine, electron microscopy, cell viability assay and in vivo thromboembolism were analyzed in great detail. Results: Carboxylated NDs evoked significant activation of human platelets. When administered intravenously in mice, NDs were found to induce widespread pulmonary thromboembolism, indicating the remarkable thrombogenic potential of this nanomaterial. Conclusion: Our findings raise concerns regarding the putative biomedical applications of NDs pertaining to diagnostics and therapeutics, and their toxicity and prothrombotic properties should be critically evaluated.

Item Type:Article
Source:Copyright of this article belongs to Future Medicine.
ID Code:100918
Deposited On:04 Feb 2017 17:26
Last Modified:04 Feb 2017 17:26

Repository Staff Only: item control page