Perspective: flicking with flow: can microfluidics revolutionize the cancer research?

Das, Tamal ; Chakraborty, Suman (2013) Perspective: flicking with flow: can microfluidics revolutionize the cancer research? Biomicrofluidics, 7 (1). Article ID 011811. ISSN 1932-1058

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Official URL: http://scitation.aip.org/content/aip/journal/bmf/7...

Related URL: http://dx.doi.org/10.1063/1.4789750

Abstract

According to the World Health Organization, cancer is one of the leading causes of death worldwide. Cancer research, in its all facets, is truly interdisciplinary in nature, cutting across the fields of fundamental and applied sciences, as well as biomedical engineering. In recent years, microfluidics has been applied successfully in cancer research. There remain, however, many elusive features of this disease, where microfluidic systems could throw new lights. In addition, some inherent features of microfluidic systems remain unexploited in cancer research. In this article, we first briefly review the advancement of microfluidics in cancer biology. We then describe the biophysical aspects of cancer and outline how microfluidic system could be useful in developing a deeper understanding on the underlying mechanisms. We next illustrate the effects of the confined environment of microchannel on cellular dynamics and argue that the tissue microconfinement could be a crucial facet in tumor development. Lastly, we attempt to highlight some of the most important problems in cancer biology, to inspire next level of microfluidic applications in cancer research.

Item Type:Article
Source:Copyright of this article belongs to American Institute of Physics.
ID Code:100694
Deposited On:06 Jan 2017 09:26
Last Modified:06 Jan 2017 09:26

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