Selvam, C. ; Jachak, Sanjay M. ; Oli, R. Gnana ; Thilagavathi, Ramasamy ; Chakraborti, Asit K. ; Bhutani, K. K. (2004) A new cyclooxygenase (COX) inhibitory pterocarpan from Indigofera aspalathoides: structure elucidation and determination of binding orientations in the active sites of the enzyme by molecular docking Tetrahedron Letters, 45 (22). pp. 4311-4314. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2004.04.010
Abstract
A new compound indigocarpan (1) and the known compound mucronulatol (2) were isolated from chloroform extracts of Indigofera aspalathoides. Their structures were established by spectroscopic methods, including single-crystal X-ray analysis (in the case of 1). The isolates were evaluated for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitory activities and antioxidant properties. The new compound 1 showed significant COX-1 inhibition (IC50 30.5 μM) and its in vivo anti-inflammatory activity was found to be comparable to that of ibuprofen. Molecular docking studies revealed the binding orientations of 1 in the active sites of COX-1 and COX-2
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 100648 |
| Deposited On: | 18 Jan 2017 11:27 |
| Last Modified: | 18 Jan 2017 11:27 |
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