Pan, Uday Narayan ; Khandelia, Rumi ; Sanpui, Pallab ; Das, Subhojit ; Paul, Anumita ; Chattopadhyay, Arun (2016) Protein-based multifunctional nanocarriers for imaging, photothermal therapy, and anticancer drug delivery ACS Applied Materials & Interfaces . No pp. given. ISSN 1944-8244
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Official URL: http://pubs.acs.org/doi/abs/10.1021/acsami.6b06099
Related URL: http://dx.doi.org/10.1021/acsami.6b06099
Abstract
We report a simple approach for fabricating plasmonic and magneto-luminescent multifunctional nanocarriers (MFNCs) by assembling gold nanorods, iron oxide nanoparticles, and gold nanoclusters within BSA nanoparticles. The MFNCs showed self-tracking capability through single- and two-photon imaging, and the potential for magnetic targeting in vitro. Appreciable T2-relaxivity exhibited by the MFNCs indicated favorable conditions for magnetic resonance imaging. In addition to successful plasmonic-photothermal therapy of cancer cells (HeLa) in vitro, the MFNCs demonstrated efficient loading and delivery of doxorubicin to HeLa cells leading to significant cell death. The present MFNCs with their multimodal imaging and therapeutic capabilities could be eminent candidates for cancer theranostics.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| Keywords: | Cancer Theranostics; Magnetic Targeting; Multifunctional Nanocarriers; Photoluminescence; Photothermal Therapy; Two Photon Imaging |
| ID Code: | 100604 |
| Deposited On: | 15 Dec 2016 10:26 |
| Last Modified: | 16 Dec 2016 10:32 |
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