Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

Kar, Shantimoy ; Ghosh, Uddipta ; Maiti, Tapas Kumar ; Chakraborty, Suman (2015) Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc Lab Chip, 15 (24). pp. 4571-4577. ISSN 1473-0197

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015...

Related URL: http://dx.doi.org/10.1039/c5lc00968e

Abstract

We investigate the deformation characteristics of red blood cells (RBCs) on a rotating compact disc platform. Our study brings out the interplay between haemoglobin content and RBC deformability in a centrifugally actuated microfluidic environment. We reveal that RBC deformations follow the similar trend of principal stress distributed throughout the radial direction, rendering an insight into the mechano-physical processes involved. This study can be used as a diagnostic marker to determine haematological disorders in diseased blood samples tested on compact disc based microfluidic platforms.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:100293
Deposited On:08 Nov 2016 05:26
Last Modified:20 Dec 2016 08:12

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