An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines

Tanwar, Babita ; Purohit, Priyank ; Raju, Banothu Naga ; Kumar, Dinesh ; Kommi, Damodara N. ; Chakraborti, Asit K. (2015) An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines RSC Advances, 5 (16). pp. 11873-11883. ISSN 2046-2069

Full text not available from this repository.

Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015...

Related URL: http://dx.doi.org/10.1039/C4RA16568C

Abstract

A new synthetic strategy of tandem N-aroylmethylation-nitro reduction–cyclocondensation has been developed for the first and generalized regioselective synthesis of 2-aryl quinoxalines adopting “all water chemistry.” Water plays the critical role through hydrogen bond driven ‘synergistic electrophile–nucleophile dual activation’ for chemoselective N-aroylmethylation of o-nitroanilines, that underlines the origin of the regioselectivity, as the use of organic solvents proved to be ineffective. Water also provides beneficial effects during the nitro reduction and the penultimate cyclocondensation steps.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:100248
Deposited On:20 Jan 2017 09:36
Last Modified:20 Jan 2017 09:36

Repository Staff Only: item control page