Avaronnan, Harishchandran ; Bhattaram, Pallavi ; Ramakrishnan, Nagaraj (2002) A synthetic strategy for on-resin amino acid specific multiple fatty acid acylation of peptides Protein and Peptide Letters, 9 (5). pp. 411-417. ISSN 0929-8665
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Official URL: http://www.benthamdirect.org/pages/content.php?PPL...
Abstract
Covalent modification with fatty acids is observed in several proteins that play crucial roles in cellular physiology. In this paper, a convenient method for the generation of multiple fatty acylated synthetic peptides is described. Peptides were synthesized using solid phase procedures with fluorenylmethoxycarbonyl α-amino protected amino acids. Acetamidomethyl protected cysteines were employed. The thiol protecting group was selectively deprotected and acylation was carried out on the resin-bound peptides. The strategy described in this report is applicable to any peptide sequence.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science Publishers. |
| Keywords: | Acylation; Myristic Acid; Palmitic Acid; Multiple Acylation; Peptide Synthesis |
| ID Code: | 87164 |
| Deposited On: | 16 Mar 2012 03:56 |
| Last Modified: | 16 Mar 2012 03:56 |
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