S11-02 activity and signalling in the development of neural morphology and locomotion

Abstract

In trying to understand how neural networks develop, work has largely focused on identifying mechanisms that specify the cell fate and morphogenesis of each unit followed by efforts to decipher how these units are connected. These studies have been invaluable in providing us an understanding of how the anatomy or the 'form' of neural networks are put in place. We know much less about how this form relates to the development of function. We are at very early stages in our attempts to integrate an understanding of how neuronal form, physiology and connectivity are related to the development of coordinated locomotion. Using an identified neuron, I will begin by briefly summarizing how activity and Wnt signalling pathways act together to develop neuronal arbors. Next, using the adult motor system of Drosophila as an example, I will summarize progress on how activity and signalling pathways work to control the development of adult walking behaviour.