Porphyrin synthesis in drug induced hepatic porphyria

Satyanarayana Rao, M. R. ; Padmanaban, G. ; Sarma, P. S. (1971) Porphyrin synthesis in drug induced hepatic porphyria Biochemical Pharmacology, 20 (8). pp. 2001-2007. ISSN 0006-2952

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-2952(71)90399-6

Abstract

Liver δ-aminolaevulate (ALA) synthetase and ALA dehydratase are induced to a greater extent in 3,5-diethoxy carbonyl-1,4-dihydrocollidine (DDC) injected mice as compared to the allyl isopropyl acetamide (AIA) injected rats. DDC treated mice do not show an increase in porphobilinogen (PEG) levels commensurate with the increase in ALA levels and the two enzyme activities, but accumulate enormous quantities of protoporphyrin in the liver. Normal mouse liver has an inherent greater capacity to convert PBG to porphyrins as compared to that of the rat. This together with the inhibition of iron incorporation into protoporphyrin in vivo at later stages of DDC administration can account for the large accumulation of protoporphyrin in these animals.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:33691
Deposited On:18 Apr 2011 19:28
Last Modified:17 Jul 2012 12:45

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