Pal, Sudip ; Chakraborty, Tushar Kanti (2014) Toward the total synthesis of a lagunamide B analogue Tetrahedron Letters, 55 (24). pp. 3469-3472. ISSN 00404039
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Official URL: http://doi.org/10.1016/j.tetlet.2014.04.079
Related URL: http://dx.doi.org/10.1016/j.tetlet.2014.04.079
Abstract
Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin’s aldol are some of the key reactions featured in this synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| Keywords: | Macrolactonization;Macrolactamization;Horner–Wadsworth–Emmons olefination;Crimmin’s aldol2-Methyl-6-nitrobenzoic anhydride (MNBA) |
| ID Code: | 131110 |
| Deposited On: | 02 Dec 2022 10:57 |
| Last Modified: | 02 Dec 2022 10:57 |
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