Arankalle, Vidya A. ; Kulkarni, Ruta ; Malshe, Nandini ; Palkar, Sonali ; Lalwani, Sanjay ; Mishra, Akhilesh Chandra (2019) Seroepidemiology of respiratory syncytial virus in western India with special reference to appropriate age for infant vaccination Journal of Medical Virology, 91 (8). pp. 1566-1570. ISSN 0146-6615
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Official URL: http://doi.org/10.1002/jmv.25489
Related URL: http://dx.doi.org/10.1002/jmv.25489
Abstract
Respiratory syncytial virus (RSV) causes significant infant mortality worldwide and a vaccine may be available soon. This study determined age-stratified anti-RSV antibody positivity (enzyme-linked immunosorbent assay [ELISA]) at Pune, India (cord blood-85 years). Antibody positivity declined from 100% at birth to 71.3% (3 months), and 0.7% (6 months). A significant rise was noted at 15 months (16%), 16 to 24 months (64.5%) and 4 years (95.2%) with concomitant IgM-anti-RSV positivity indicative of recent infection. Antibody decline was higher in infants born preterm than full-term. Across subsequent age groups including the elderly, antibody positivity was similar and comparable, suggestive of repeated exposure to the virus. Early protection/vaccination is essential for the infant population.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Wiley Periodicals, Inc. |
| Keywords: | antibody prevalence; maternal antibodies; preterm/full-term infants; respiratory syncytial virus |
| ID Code: | 130879 |
| Deposited On: | 01 Dec 2022 05:37 |
| Last Modified: | 01 Dec 2022 05:37 |
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