Victor, Napoleon John ; Muraleedharan, Kannoth Manheri (2014) An Expeditious and Metal-Free Synthetic Route towards Quinolones, Naphthyridones and Benzonaphthyridones Advanced Synthesis & Catalysis, 356 (17). pp. 3600-3614. ISSN 1615-4150
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Official URL: http://doi.org/10.1002/adsc.201300891
Related URL: http://dx.doi.org/10.1002/adsc.201300891
Abstract
An efficient, two-step synthetic strategy has been developed to access the quinolone, naphthyridone and benzonaphthyridone classes of chemotherapeutic agents from Baylis–Hillman adducts. The method involves tandem aza-Michael addition, SNAr cyclisation followed by oxidation of the resulting 4-hydroxy-1,2,3,4-tetrahydroquinoline or 4-hydroxy-1,2,3,4-tetrahydro-1,8-naphthyridine derivative using IBX, and works well with substrates having a wide variety of substitution pattern.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| ID Code: | 130642 |
| Deposited On: | 29 Nov 2022 04:41 |
| Last Modified: | 29 Nov 2022 04:41 |
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