Baylis-Hillman Acetates in Synthesis: Copper(I)/tert-Butyl Hydroperoxide Promoted One-Pot Oxidative Intramolecular Cyclization Protocol for the Preparation of Pyrrole-Fused Compounds and the Formal Synthesis of (±)-Crispine A

Basavaiah, Deevi ; Lingaiah, Balthu ; Reddy, Guddeti Chandrashekar ; Sahu, Bharat Chandra (2016) Baylis-Hillman Acetates in Synthesis: Copper(I)/tert-Butyl Hydroperoxide Promoted One-Pot Oxidative Intramolecular Cyclization Protocol for the Preparation of Pyrrole-Fused Compounds and the Formal Synthesis of (±)-Crispine A European Journal of Organic Chemistry, 2016 (14). pp. 2398-2403. ISSN 1434-193X

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Official URL: http://doi.org/10.1002/ejoc.201600384

Related URL: http://dx.doi.org/10.1002/ejoc.201600384

Abstract

A one-pot, four-step strategy involving alkylation, oxidation, intramolecular cyclization, and aromatization is developed for the synthesis of pyrrole-fused tri- and tetracyclic compounds by using Baylis–Hillman acetates as the starting materials. A formal synthesis of biologically active (±)-crispine A is also achieved. EWG = electron-withdrawing group.

Item Type:Article
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ID Code:130138
Deposited On:02 Dec 2022 05:57
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