Mukherjee, A.K ; Maity, C.R (2002) Biochemical composition, lethality and pathophysiology of venom from two cobras — Naja naja and N. kaouthia Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 131 (2). pp. 125-132. ISSN 10964959
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Official URL: http://doi.org/10.1016/S1096-4959(01)00473-0
Related URL: http://dx.doi.org/10.1016/S1096-4959(01)00473-0
Abstract
The cobras Naja naja and N. kaouthia are abundant in eastern and north-eastern India, accounting for maximum snakebite deaths. Here we report on variation in the composition of Naja kaouthia and N. naja venom from eastern India on corresponding differences in the severity of pathogenesis. These two venoms differ in chromatographic elution profile through Sephadex G-50 and enzyme activity, protein and carbohydrate contents associated with each fraction. The presence of greater amounts of basic phospholipase A2, l-amino acid oxidase and low molecular weight membrane active polypeptides in the N. naja venom makes it more toxic than N. kaouthia venom. A commercial polyvalent antivenom raised against N. naja venom inactivates lethality and variety of toxic effects of homologous venom more effectively than N. kaouthia venom.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science Inc. |
| Keywords: | Antivenom, Cobra venom, Membrane active polypeptides, Myonecrosis, Naja naja, Naja kaouthia, Phospholipase A2, Snake venom |
| ID Code: | 126908 |
| Deposited On: | 13 Oct 2022 08:50 |
| Last Modified: | 13 Oct 2022 08:50 |
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