Tuning the mechanical and physicochemical properties of cross‐linked protein films

Parveen, Sultana ; Chaudhury, Susmitnarayan ; Dasgupta, Swagata (2019) Tuning the mechanical and physicochemical properties of cross‐linked protein films Biopolymers, 110 (10). ISSN 0006-3525

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Official URL: http://doi.org/10.1002/bip.23321

Related URL: http://dx.doi.org/10.1002/bip.23321


Films derived from natural sources such as proteins provide an advantage over synthetic films due to their noncytotoxicity, biodegradability, and vast functionality. A new protein source gained from the cataractous eye protein isolate (CEPI) obtained after surgery has been investigated for this purpose. Glycerol has been employed as the plasticizer and glutaraldehyde (GD) as a cross-linker. Fourier transform infrared spectroscopy was employed to characterize the films. Nanoindentation and thermogravimetric analyses reveal improved mechanical and thermal properties of the cross-linked films. The films with 20% (w/w) GD exhibited properties such as the highest modulus and low water solubility. It is possible to tune the properties based on the extent of cross-linking. All the films were completely degraded by the enzyme trypsin. The similarity of these films was checked by using the prepared films as a delivery vehicle for a model compound, ampicillin sodium. The encapsulation efficiency was found to be 74%, and in vitro release studies showed significant amounts of drug release at physiological pH. This study will help us understand how the properties of protein films can be tuned to obtain the desired physicochemical properties. These biodegradable protein films could find use in pharmaceutical industries as delivery carriers.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc.
ID Code:123634
Deposited On:10 Oct 2021 08:47
Last Modified:10 Oct 2021 08:47

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