Reddy, D. Srinivasa ; Vander Velde, David ; Aubé, Jeffrey (2004) Synthesis and Conformational Studies of Dipeptides Constrained by Disubstituted 3-(Aminoethoxy)propionic Acid Linkers Journal of Organic Chemistry, 69 (5). pp. 1716-1719. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/jo035683q
Related URL: http://dx.doi.org/10.1021/jo035683q
Abstract
A series of cyclic compounds with dimethyl-substituted 3-(aminoethoxy)propionic acid linkers have been prepared as potential beta-turn mimics. The desired linkers were prepared from disubstituted pyrones, which were coupled with dipeptides and then subjected to macrocyclization using diethylcyanophosphonate to furnish cyclic compounds 1-5. Conformational analysis was carried out using NMR and X-ray crystallography. All of the five cyclic compounds were found to exist in type I or type II beta-turn conformations.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 122024 |
| Deposited On: | 27 Jul 2021 10:25 |
| Last Modified: | 27 Jul 2021 10:25 |
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