Sequential combination of Michael and acetalization reactions: direct catalytic asymmetric synthesis of functionalized 4-nitromethyl-chromans as drug intermediates

Ramachary, Dhevalapally B. ; Sakthidevi, Rajasekar (2010) Sequential combination of Michael and acetalization reactions: direct catalytic asymmetric synthesis of functionalized 4-nitromethyl-chromans as drug intermediates Organic and Biomolecular Chemistry, 8 (19). p. 4259. ISSN 1477-0520

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Official URL: http://doi.org/10.1039/C0OB00189A

Related URL: http://dx.doi.org/10.1039/C0OB00189A

Abstract

Functionalized chiral 4-nitromethyl-chromans as drug intermediates were achieved for the first time through sequential combination of Michael and acetalization reactions on 2-(2-nitro-vinyl)-phenols with acetone and alcohols in the presence of a catalytic amount of 9-amino-9-deoxyepiquinine and Ph2CHCO2H followed by p-TSA.

Item Type:Article
Source:Copyright of this article belongs to The Royal Society of Chemistry.
ID Code:120766
Deposited On:05 Jul 2021 05:53
Last Modified:05 Jul 2021 05:53

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