Acid-Controlled Chemodivergent Synthesis of Three Differently Substituted Quinolines via Site Selective Coupling of ortho- Aminoaryl Ketones with α-Enolic Dithioesters

Abstract

A straightforward approach for the chemodivergent synthesis of quinolines is described through site-selective coupling of ortho-aminoaryl ketones with α-enolic dithioesters (DTEs) under solvent-free conditions. The operationally and user-simple one-pot methodology is based on the trifunctional nature of DTEs. Both the carbonyl and the thiocarbonyl moiety in α-enolic dithioesters were employed for the efficient construction of three differently substituted quinolines in a chemoselective manner simply by variation of an easy to handle acid catalyst.