DMAP-promoted domino annulation of β-ketothioamides with internal alkynes: a highly regioselective access to functionalized 1,3-thiazolidin-4-ones at room temperature

Verma, Girijesh Kumar ; Shukla, Gaurav ; Nagaraju, Anugula ; Srivastava, Abhijeet ; Raghuvanshi, Keshav ; Singh, Maya Shankar (2014) DMAP-promoted domino annulation of β-ketothioamides with internal alkynes: a highly regioselective access to functionalized 1,3-thiazolidin-4-ones at room temperature RSC Advances, 4 (23). pp. 11640-11647. ISSN 2046-2069

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Official URL: http://doi.org/10.1039/C4RA00131A

Related URL: http://dx.doi.org/10.1039/C4RA00131A

Abstract

DMAP-mediated rapid and efficient one-pot regioselective access to functionalized 1,3-thiazolidin-4-ones via annulation of β-ketothioamides with internal alkynes has been achieved under mild reaction conditions. The merit of this straightforward domino protocol is highlighted by its operational simplicity, short reaction time, tolerance of a large variety of functional groups, and efficiency of producing two new bonds (C–S and C–N) and one thiazolidine ring.

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