Enantioselective formal synthesis of palmerolide A

Prasad, Kavirayani R. ; Pawar, Amit B. (2011) Enantioselective formal synthesis of palmerolide A Organic Letters, 13 (16). pp. 4252-4255. ISSN 1523-7060

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol201604c

Related URL: http://dx.doi.org/10.1021/ol201604c

Abstract

Enantioselective formal synthesis of macrolactone palmerolide A, a polyketide marine natural product, is described. Key strategies in the synthesis include the oxidative furan ring-opening of a chiral furyl carbinol for the installation of the 1,4-dienol core and a Jung nonaldol–aldol reaction for the dienamide core.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:105693
Deposited On:21 Dec 2017 12:03
Last Modified:21 Dec 2017 12:03

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