Pataskar, Shashank S. ; Dash, Debasis ; Brahmachari, Samir K. (2001) Intramolecular i-motif structure at acidic pH for progressive myoclonus epilepsy (EPM1) repeat d(CCCCGCCCCGCG)n Journal of Biomolecular Structure & Dynamics, 19 (2). pp. 307-314. ISSN 0739-1102
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Official URL: http://www.jbsdonline.com/c3008/c4016/Intramolecul...
Abstract
The most common mutation associated with Progressive Myoclonus Epilepsy (EPM1) of Unverricht-Lundberg type is the expansion of a dodecamer repeat, d(CCCCGCCCCGCG)n. We show that the C-rich strand of this repeat (2-3 copies) forms intercalated i-motif structure at acidic pH as judged by CD spectroscopy and anomalous gel electrophoretic mobility. The stability of the structure increases with the increase in the length of the repeat. Transient formation of stable, folded back structure like i-motif could play an important role in the mechanism of expansion of this repeat.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Adenine Press. |
| ID Code: | 96172 |
| Deposited On: | 17 Dec 2012 09:14 |
| Last Modified: | 17 Dec 2012 09:14 |
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