Pramanick, Swapan ; Roy, Amit ; Ghosh, Shekher ; Majumder, Hemanta K. ; Mukhopadhyay, Sibabrata (2008) Withanolide Z, a new chlorinated withanolide from Withania somnifera Planta Medica, 74 (14). pp. 1745-1748. ISSN 0032-0943
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-2008-1081357
Abstract
Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5). Their structures were elucidated by IR, MS, CD and a combination of 1 D and 2 D NMR spectral analyses. The Leishmania donovani DNA topoisomerase I inhibitory activities of the isolated compounds were determined.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Withania somnifera; Withanolide; HPLC; Leishmania donovani DNA Topoisomerase I |
| ID Code: | 87825 |
| Deposited On: | 22 Mar 2012 07:55 |
| Last Modified: | 22 Mar 2012 07:55 |
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