A study of bacteremia in febrile neutropenic patients at a tertiary-care hospital with special reference to anaerobes

Mathur, P. ; Chaudhry, R. ; Kumar, L. ; Kapil, A. ; Dhawan, B. (2002) A study of bacteremia in febrile neutropenic patients at a tertiary-care hospital with special reference to anaerobes Medical Oncology, 19 (4). pp. 267-272. ISSN 1357-0560

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Official URL: http://www.springerlink.com/content/a7q61005r73366...

Related URL: http://dx.doi.org/10.1385/MO:19:4:267

Abstract

Patients with hematological malignancies who are receiving chemotherapy suffer prolonged periods of neutropenia, which leads to a greater risk of infection and mortality. A prospective study was conduced to determine the incidence of bacteremia in patients of hematological malignancies over a 2-yr period. A total of 119 episodes of febrile neutropenia occurred among 96 consecutive patients, of which 35 episodes were associated with bacteremia. Forty-four percent of the isolated bacteria were Gram-positive aerobes and 46% were Gram-negative aerobes. Staphylococcus aureus, Enterococcus spp., and Escherichia coli were the most common isolates. Gram-negative bacteremia was associated with a higher mortality. Anaerobes accounted for 4.4% of all isolates. The episodes of anaerobic bacteremia were polymicrobial and had a fatal outcome. A high incidence of antimicrobial resistance among aerobic and anaerobic bacteria was also recorded. Compared to previous years, a shift from a predominating Gram-negative to a Gram-positive etiology was noted. The initial empiric antibiotic regimens should be based on a local knowledge of the most common causative microorganisms, their sensitivity pattern, and the outcome of bacteremia.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Bacteremia; Febrile Neutropenia; Hematological Malignancies; Anaerobes; Antimicrobial Resistance
ID Code:86451
Deposited On:10 Mar 2012 13:14
Last Modified:10 Mar 2012 13:14

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