Mugesh, Govindasamy ; du Mont, Wolf-Walther (2001) Structure-activity correlation between natural glutathione peroxidase (GPx) and mimics: a biomimetic concept for the design and synthesis of more efficient GPx mimics Chemistry - A European Journal, 7 (7). pp. 1365-1370. ISSN 0947-6539
Full text not available from this repository.
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/1521-37...
Related URL: http://dx.doi.org/10.1002/1521-3765(20010401)7:7<1365::AID-CHEM13657gt;3.0.CO;2-Y
Abstract
Among the organoselenium compounds that mimic the action of the natural enzyme glutathione peroxidase (GPx), there are certain basic differences in the activity, substrate specificity and mechanism. These differences arise mainly from the nature of the substituents near the reaction center, and stability and reactivity of the intermediates. As an attempt to draw some general concepts for the development of new mimics, a structure-activity correlation between natural GPx and some existing mimics is described.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to John Wiley and Sons. |
Keywords: | Enzyme Models; Glutathione Peroxidase; Selenium; Selenoenzymes; Structure-activity Relationships |
ID Code: | 79345 |
Deposited On: | 25 Jan 2012 05:58 |
Last Modified: | 25 Jan 2012 05:58 |
Repository Staff Only: item control page