Manna, Debasish ; Mugesh, Govindasamy (2010) A chemical model for the inner-ring deiodination of thyroxine by iodothyronine deiodinase Angewandte Chemie International Edition, 49 (48). pp. 9246-9249. ISSN 1433-7851
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/anie.20...
Related URL: http://dx.doi.org/10.1002/anie.201005235
Abstract
The I of the beholder: The presented chemical model for the inner-ring deiodination of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) by iodothyronine deiodinase (see scheme) highlights the importance of an in-built thiol group in proximity to the selenium atom. The effective removal of iodine in the case of T4 indicates that an enol-keto tautomerism is not required for deiodination.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Enzyme Models; Hormones; Iodine; Selenium; Thyroxine |
| ID Code: | 79297 |
| Deposited On: | 25 Jan 2012 06:35 |
| Last Modified: | 25 Jan 2012 06:35 |
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