Trimethylsilyl iodide as a peptide deblocking agent

Lott, Richard S. ; Chauhan, Virander S. ; Stammer, Charles H. (1979) Trimethylsilyl iodide as a peptide deblocking agent Journal of the Chemical Society, Chemical Communications (11). pp. 495-496. ISSN 0022-4936

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Official URL: http://pubs.rsc.org/en/content/articlepdf/1979/c3/...

Related URL: http://dx.doi.org/10.1039/C39790000495

Abstract

Removal of urethane and benzyl ether blocking groups from peptides is readily accomplished by treatment with trimethylsilyl iodide which is particularly useful for the debenzylation of O-benzyltyrosine without the formation of rearrangement products.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:77506
Deposited On:12 Jan 2012 14:35
Last Modified:12 Jan 2012 14:35

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