Haveli, Shrutisagar Dattatraya ; Roy, Sudipta ; Chandrasekaran, Srinivasan (2009) Synthesis of unnatural C-2 amino acid nucleosides using NIS-mediated ring opening of 1,2-cyclopropane carboxylated sugar derivatives Synlett (3). pp. 451-455. ISSN 0936-5214
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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...
Related URL: http://dx.doi.org/10.1055/s-0028-1087545
Abstract
We have developed a general and efficient method for the stereoselective construction of pyrimidine-based pyranosyl C-2 amino acid nucleosides using NIS-mediated ring opening of 1,2-cyclopropanated sugar derivatives. This methodology has been successfully extended to the synthesis of furanosyl nucleosides, which have potential applications in the development of novel, nontoxic antifungal therapeutics.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Amino Acid Nucleoside; Donor-acceptor; Polyoxin; Purine; Pyrimidine |
| ID Code: | 7311 |
| Deposited On: | 25 Oct 2010 11:50 |
| Last Modified: | 01 Feb 2011 09:11 |
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