Guo, Qin ; Chandrasekhar, Jayaraman ; Ihle, David ; Wustrow, David J. ; Chenard, Bertrand L. ; Krause, James E. ; Hutchison, Alan ; Alderman, Dawn ; Cheng, Charles ; Cortright, Daniel ; Broom, Daniel ; Kershaw, Mark T. ; Simmermacher-Mayer, Jean ; Peng, Yao ; Hodgetts, Kevin J. (2008) 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B1 receptor antagonists Bioorganic & Medicinal Chemistry Letters, 18 (18). pp. 5027-5031. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2008.08.014
Abstract
The design, synthesis, and structure-activity studies of a novel series of BK B1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B1 receptor were discovered.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Bradykinin B; P-glycoprotein; 1-Benzylbenzimidazole |
| ID Code: | 7181 |
| Deposited On: | 25 Oct 2010 12:20 |
| Last Modified: | 04 Feb 2011 04:45 |
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