Manjeet, Rao ; Ghosh, K. B. (1999) Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophages International Journal of Immunopharmacology, 21 (7). pp. 435-443. ISSN 0192-0561
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0192-0561(99)00024-7
Abstract
High amounts of nitric oxide and TNF-α generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-α and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-α and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Tumor Necrosis Factor-α (TNF-α); Nitric Oxide (NO); Quercetin; Rhododendron Cinnabarium; Bacterial Lipopolysaccharide (LPS) |
| ID Code: | 66067 |
| Deposited On: | 21 Oct 2011 03:28 |
| Last Modified: | 21 Oct 2011 03:28 |
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