Jagannathan, N. R. ; Wadhwa, Sanjay (2002) In vivo proton magnetic resonance spectroscopy (MRS) study of post polio residual paralysis (PPRP) patients Magnetic Resonance Imaging, 20 (1). pp. 113-117. ISSN 0730-725X
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0730-725X(02)00480-0
Abstract
In-vivo proton MR spectroscopy carried out on post polio residual paralysis (PPRP) patients indicate that the presence or absence of intra-myocellular lipids (IMCL) is related to the severity of the paralysis. It is observed that mildly paralyzed patients are comparable (p > 0.05) with the control subjects in relation to the presence of IMCL, while moderate and severely paralysed patients are comparable (p > 0.05) in relation to the absence of IMCL. In addition, there is reduction or complete absence of creatine, carnitine and choline metabolites in severely paralyzed patients. The ability to detect noninvasively the subtle differences in in vivo, the lipid compartments of muscle may prove to be a valuable tool in understanding the pathogenesis of muscle diseases. This could open up the possibilities in designing effective rehabilitative exercise programs or development of new drug therapies.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Post Polio Residual Paralysis (PPRP); Intra-myocellular Lipid (IMCL); Extra-myocellular Lipid (EMCL); Proton MR Spectroscopy; Gastrocnemius |
ID Code: | 65872 |
Deposited On: | 19 Oct 2011 14:27 |
Last Modified: | 19 Oct 2011 14:27 |
Repository Staff Only: item control page