Kotha, Sambasivarao ; Brahmachary, Enugurthi (2002) Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy Bioorganic & Medicinal Chemistry, 10 (7). pp. 2291-2295. ISSN 0968-0896
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0968-0896(02)00039-1
Abstract
A simple synthesis of dialkyne building blocks (6, 7, 8 and 9) embodying amino acid moiety is described. The dialkyne 6 participated in a [2+2+2] cycloaddition reaction with various monoalkynes in presence of Wilkinson's catalyst to give 5- and 5,6-disubstituted indan-based a-amino acid derivatives. Cobalt catalyst [e.g., CpCo(CO)2] has also been employed in the synthesis of various 2-indanyl glycine derivatives via co-trimerization reaction of the diyne building blocks 6 and 7 with several monoalkynes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 65159 |
| Deposited On: | 15 Oct 2011 11:40 |
| Last Modified: | 15 Oct 2011 11:40 |
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