Three-component coupling reactions in ionic liquids: an improved protocol for the synthesis of 1,4-dihydropyridines

Yadav, J. S. ; Reddy, B. V. S. ; Basak, A. K. ; Narsaiah, A. V. (2003) Three-component coupling reactions in ionic liquids: an improved protocol for the synthesis of 1,4-dihydropyridines Green Chemistry, 5 (1). pp. 60-63. ISSN 1463-9262

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2003...

Related URL: http://dx.doi.org/10.1039/B210017G

Abstract

Three-component condensation of aldehyde, β-ketoester and methyl 3-aminocrotonate proceeds smoothly in 1-n-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 or 1-n-butyl-3-methylimidazolium hexafluorophosphate [bmim]PF6 ionic liquids at room temperature under mild conditions to afford the corresponding 1,4-dihydropyridine derivatives in high yields. The recovered activated ionic liquids are recycled for four to five runs with no loss in activity.

Item Type:Article
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Deposited On:28 Sep 2011 03:20
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