Yadav, J. S. ; Subba Reddy, B. V. ; Ramesh Reddy, A. ; Narsaiah, A. V. (2007) Iodine as a mild, efficient, and cost-effective reagent for the synthesis of cis-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acids Synthesis, 2007 (20). pp. 3191-3194. ISSN 0039-7881
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-2007-983899
Abstract
Arylimines generated in situ from aromatic aldehydes and anilines undergo smooth coupling with homophthalic anhydride in the presence of 10 mol% of molecular iodine under mild and neutral conditions to afford the corresponding cis-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acids in excellent yields with high cis selectivity. The use of iodine makes this procedure simple, convenient, and cost-effective.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Three-component Reaction; Iodine; Isoquinolines; Heterocycles; Carboxylic Acids |
| ID Code: | 63202 |
| Deposited On: | 28 Sep 2011 03:34 |
| Last Modified: | 28 Sep 2011 03:34 |
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