Yadav, J. S. ; Naga Lakshmi, P. (2010) A concise approach for the synthesis of core fragment C7-C15 of (+)-migrastatin using desymmetrization strategy Synlett, 2010 (7). pp. 1033-1036. ISSN 0936-5214
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-0029-1219785
Abstract
The core fragment C7-C15 the (+)-migrastatin was constructed in a stereoconvergent manner utilizing desymmetrization approach. The strategy involved the generation of Z-configuration of trisubstituted double bond at C11-C12, epimerization at C10, ring opening of the pyran lactol with C2 Wittig ylide, and regioselective Sharpless dihydroxylation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | (+)-migrastatin; Desymmetrization; Epimerization; Sharpless Asymmetric Dihydroxylation |
| ID Code: | 63157 |
| Deposited On: | 28 Sep 2011 03:45 |
| Last Modified: | 28 Sep 2011 03:45 |
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