Yadav, J. S. ; Samad Hossain, Sk. ; Madhu, Madasu ; Mohapatra, Debendra K. (2009) Formal total synthesis of (-)-saliniketals Journal of Organic Chemistry, 74 (22). pp. 8822-8825. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo901913h
Related URL: http://dx.doi.org/10.1021/jo901913h
Abstract
A highly stereoselective formal total synthesis of the ornithine decarboxylase inhibitors (-)-saliniketals A and B is described. The salient features of the synthesis are the utilization of a desymmetrization technique to create six contiguous chiral centers from a single bicyclic precursor as well as substrate-controlled Grignard reaction, intramolecular Wacker-type oxidation, and antialdol reaction following Pirrung-Heathcock conditions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 62818 |
| Deposited On: | 24 Sep 2011 05:00 |
| Last Modified: | 24 Sep 2011 05:00 |
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