Efficient synthesis of optically active 2-azido-1-arylethanols via oxazaborolidine-catalysed asymmetric borane reduction

Yadav, J. S. ; Thirupathi Reddy, P. ; Riaz Hashim, S. (2007) Efficient synthesis of optically active 2-azido-1-arylethanols via oxazaborolidine-catalysed asymmetric borane reduction Synlett, 2007 (7). pp. 1049-1051. ISSN 0936-5214

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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...

Related URL: http://dx.doi.org/10.1055/s-2000-6659

Abstract

A simple, efficient, stereo- and regio-selective method for the synthesis of optically active 2-azido-1-phenylethanols by asymmetric reduction of 2-azidoacetophenones with in situ generated, oxazaborolidine-borane complexes in THF, is described. This new method appears to be an alternative to the classical methods previously reported.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers.
Keywords:α-azidoarylketones; Oxazaborolidine Catalyst; 1-azido-2-arylethanols; Asymmetric Borane Reduction; (s)-diphenylprolinol
ID Code:62773
Deposited On:24 Sep 2011 04:53
Last Modified:24 Sep 2011 04:53

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