Shivashankar, G. V. ; Stolovitzky, G. ; Libchaber, A. (1998) Backscattering from a tethered bead as a probe of DNA flexibility Applied Physics Letters, 73 (3). pp. 291-293. ISSN 0003-6951
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Official URL: http://apl.aip.org/resource/1/applab/v73/i3/p291_s...
Related URL: http://dx.doi.org/10.1063/1.121798
Abstract
Using an optical tweezer, we trap a DNA polymer tethered bead. Collinear with the tweezer, a red laser light beam probes the bead fluctuations through backscattered radiation measurement. Those fluctuations give information on the flexibility of DNA and can be used to probe the interaction of proteins with DNA. We use this approach to directly monitor the extension of a single DNA polymer beyond its contour length induced by the polymerization of Rec A protein on DNA.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Institute of Physics. |
| Keywords: | Backscatter; DNA; Fluctuations |
| ID Code: | 62278 |
| Deposited On: | 20 Sep 2011 09:36 |
| Last Modified: | 20 Sep 2011 09:36 |
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