Yadav, J. S. ; Satheesh Babu, R. ; Sabitha, G. (2003) Stereoselective total synthesis of (+)-artemisinin Tetrahedron Letters, 44 (2). pp. 387-389. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(02)02500-5
Abstract
The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Artemisinin; Stereoselective; Iodolactone; Tris(trimethylsilyl)silane |
| ID Code: | 60401 |
| Deposited On: | 09 Sep 2011 03:50 |
| Last Modified: | 09 Sep 2011 03:50 |
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