Edison, Eunice Sindhuvi ; Shaji, Ramachandran V. ; Srivastava, Alok ; Chandy, Mammen (2005) Hyperbilirubinemia in homozygous Hbe disease is associated with the UGT1A1 gene polymorphism Hemoglobin, 29 (3). pp. 189-195. ISSN 0363-0269
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Official URL: http://www.informahealthcare.com/doi/abs/10.1081/H...
Related URL: http://dx.doi.org/10.1081/HEM-200066314
Abstract
Homozygous HbE [β26(B8)Glu → Lys] is a clinically mild disorder with no significant symptoms. However, we have frequently noted hyperbilirubinemia among patients with homozygous HbE in the Indian population, with jaundice being the major complaint at presentation. A study of the UGT1A1 gene polymorphism shows that the variant TA7 in the promoter region of the UGT1A1 gene is associated with hyperbilirubinemia in homozygous HbE patients.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa Healthcare. |
| Keywords: | HbE; Hyperilirubinemia; UGT1A1 Gene Polymorphism; India |
| ID Code: | 5920 |
| Deposited On: | 19 Oct 2010 10:12 |
| Last Modified: | 29 Jan 2011 04:54 |
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