Iodine as novel reagent for the 1,2-addition of trimethylsilyl cyanide to ketones including α,β-unsaturated ketones

Yadav, J. S. ; Reddy, B. V. S. ; Sridhar Reddy, M. ; Prasad, A. R. (2002) Iodine as novel reagent for the 1,2-addition of trimethylsilyl cyanide to ketones including α,β-unsaturated ketones Tetrahedron Letters, 43 (52). pp. 9703-9706. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)02321-3

Abstract

Molecular iodine is found to catalyze efficiently the addition of trimethylsilyl cyanide to a range of simple and functionalized ketones under very mild and convenient conditions to afford the corresponding cyanohydrin trimethylsilyl ethers in excellent yields in a short reaction period with high selectivity. α,β-Unsaturated ketones selectively afford the corresponding 1,2-adducts without the formation of 1,4-adducts under similar reaction conditions.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Ketones; Trimethylsiyl Cyanide; Iodine; α-cyanohydrins
ID Code:58925
Deposited On:02 Sep 2011 03:15
Last Modified:02 Sep 2011 03:15

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