Rana, Nirmal K. ; Selvakumar, Sermadurai ; Singh, Vinod K. (2010) Highly enantioselective organocatalytic sulfa-Michael addition to α,β-unsaturated ketones The Journal of Organic Chemistry, 75 (6). pp. 2089-2091. ISSN 0022-3263
Full text not available from this repository.
Official URL: http://pubs.acs.org/doi/abs/10.1021/jo902634a
Related URL: http://dx.doi.org/10.1021/jo902634a
Abstract
A cinchona alkaloid-derived urea was found to be an efficient organocatalyst for catalyzing enantioselective conjugate addition between thiols and various α,β-unsaturated ketones to provide optically active sulfides with high chemical yields (up to >99%) and enantiomeric excess (up to >99% ee). The reaction was performed with 0.1 mol % of catalyst in toluene at room temperature. A transition state model has been proposed to explain the stereochemical outcome of the reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 55446 |
| Deposited On: | 18 Aug 2011 08:49 |
| Last Modified: | 18 Aug 2011 08:49 |
Repository Staff Only: item control page
