Bisai, Alakesh ; Singh, Vinod K. (2006) Enantioselective one-pot three-component synthesis of propargylamines Organic Letters, 8 (11). pp. 2405-2408. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol060793f
Related URL: http://dx.doi.org/10.1021/ol060793f
Abstract
A copper(I) complex of i-Pr-pybox-diPh has been found to be an efficient catalyst for an enantioselective one-pot three-component synthesis of propargylamines from aldehydes, amines, and alkynes. The reaction has been applied to a wide variety of aromatic aldehydes with excellent yields (up to 99%) and enantiomeric excesses (up to 99% ee). A transition-state model has been proposed to explain the stereochemical outcome of the reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 55409 |
| Deposited On: | 18 Aug 2011 08:43 |
| Last Modified: | 18 Aug 2011 08:43 |
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