Narayanan, Sriram ; Surendranath, Kalpana ; Bora, Namrata ; Surolia, Avadhesha ; Karande, Anjali A. (2005) Minireview ribosome inactivating proteins and apoptosis FEBS Letters, 579 (6). pp. 1324-1331. ISSN 0014-5793
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.febslet.2005.01.038
Abstract
Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied. Comparison of pathways of apoptosis and cellular events induced by various RIPs suggests a central role played by mitochondria, probably acting as an integrator of cellular stress and cell death. The purpose of this review is to compare the various apoptotic pathways that may be involved and propose a general pathway in RIP-induced cell death.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Ribosome Inactivating Protein; Protein Synthesis Inhibition; Ribosome Inactivation; Ribotoxic Stress Response; Mitochondrial Stress; Apoptosis |
| ID Code: | 55247 |
| Deposited On: | 18 Aug 2011 12:07 |
| Last Modified: | 18 Aug 2011 12:07 |
Repository Staff Only: item control page
