Conversion of carbonimidodithioates into unsymmetrical di- and tri- substituted ureas including urea dipeptides

Anbazhagan, Mariappan ; Deshmukh, Abdul Rakeeb A. S. ; Rajappa, Srinivasachari (1998) Conversion of carbonimidodithioates into unsymmetrical di- and tri- substituted ureas including urea dipeptides Tetrahedron Letters, 39 (21). pp. 3609-3612. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(98)00561-9

Abstract

Selective hydrolysis of carbonimidodithioates (3) leads to the thiocarbamates (4), which can be easily transformed to the unsymmetrical ureas (5) by treatment with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene or carbon monoxide.

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