Mitra-Kaushik, Shibani ; Shaila, M. S. ; Karande, Anjali ; Nayak, Rabindranath (2001) Idiotypic-anti-idiotypic B cell interactions generated against a protective antigen of a morbillivirus in mice Cellular Immunology, 209 (1). pp. 10-18. ISSN 0008-8749
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1006/cimm.2001.1788
Abstract
The idiotypic network theory (N. K. Jerne, Ann. Immunol. 125, 373-389, 1974) predicts that any antibody that can be made by an individual would have its preexisting specific complementary B cells in its germline repertoire. We transplanted syngeneic BALB/c mice with live hybridoma cells and demonstrated the simultaneous presence of interacting idiotypic and anti-idiotypic B cells in an individual animal by immuno-cytoadherence assays. Furthermore, we demonstrate that interacting B cells displaying idiotypic and anti-idiotypic antibodies are subjected to lysis by complement. It is therefore tempting to speculate that this complement-sensitive interaction between idiotypic and complementary anti-idiotypic B cells in vivo may provide a mechanism for the regulation of B cell populations.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Idiotypic Antibody; Anti-idiotypic Antibody; B Cell Regulation |
| ID Code: | 49282 |
| Deposited On: | 19 Jul 2011 13:59 |
| Last Modified: | 19 Jul 2011 13:59 |
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